By Jay D. Humphrey, Sherry L. O'Rourke
This e-book covers the basics of biomechanics. subject matters contain bio solids, biofluids, tension, stability and equilibrium. scholars are inspired to contextualize rules and routines inside a “big photograph” of biomechanics. this is often a terrific ebook for undergraduate scholars with pursuits in biomedical engineering.
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Extra info for An Introduction to Biomechanics: Solids and Fluids, Analysis and Design
Clearly, there is a pressing need for more data on the mechanical properties of cells; fortunately, experimental tools such as laser tweezers (see Chap. 3) and the atomic force microscope (Chap. 5) allow increased insight into cell mechanics and, indeed, the various intracellular constituents, which includes actin ﬁlaments, intermediate ﬁlaments, microtubules, the plasma membrane, and even the cytosol. , how individual molecules respond to applied loads). Zhu et al. (2000) point out, for example, that in response to applied loads, a molecule may rotate/translate, it may deform, or it may unfold/refold.
On the natural scale of observation, we see and can think of the water as a continuous medium. In reality, however, we know that water is a collection of discrete, interacting molecules composed of hydrogen and oxygen atoms, and we know that there are gaps between the H2O molecules and even gaps between the electrons and nucleus of each of the atoms. In statistical mechanics, we attempt to describe the (statistical) mean behavior of the individual molecules so as to understand gross behaviors on a natural scale of observation.
This terminology was coined by Hooke (1635–1703) who was perhaps the ﬁrst to describe a cellular structure, which in his case was remnant cell walls in a thin 2 Much of Sects. 5 are from Humphrey (2002). 12 1. 5 Schema of a mammalian cell showing its three primary constituents: the cell membrane (with various receptors, pumps, channels, and transmembrane proteins), the cytoplasm (including many different types of organelles, the cytoskeleton, and the cytosol), and the nucleus. From a mechanics perspective, the three primary proteins of the cytoskeleton (actin, intermediate ﬁlaments, and microtubules) are of particular importance.