Aminocyclitol Antibiotics by Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)

By Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)

content material: Aminocyclitol antibiotics : an advent / Kenneth L. Rinehart, Jr. and Lois S. safeguard --
Synthesis of aminocyclitol antibiotics / S. Umezawa --
amendment of aminocyclitol antibiotics / Tetsuo Suami --
Syntheses of some branched-chain aminocyclitol antibiotics / Juji Yoshimura, Masuo Funabashi, and Chung-Gi Shin --
a brand new synthesis of branched-chain epi-configuration deoxyhalogeno- and deoxyaminocyclitols / Donald E. Kiely and James M. Riordan --
The stereospecific synthesis of spectinomycin / D.R. White, R.D. Birkenmeyer, R.C. Thomas, S.A. Mizsak, and V.H. Wiley --
Synthesis of spectinomycin analogs / R.C. Thomas, D.R. White, V.H. Wiley, and D.A. Forster --
Spectinomycin amendment / W. Rosenbrook, Jr. and Ronald E. Carney --
The buildings of diastereomers of dihydrospectinomycins / Louise Foley and Manfred Weigele --
Chemical amendment of aminoglycosides : a singular synthesis of 6-deoxyaminoglycosides / Barney J. Magerlein --
The impression of O-methylation at the task of aminoglycosides / J.B. McAlpine, R.E. Carney, R.L. Devault, A.C. Sinclair, R.S. Egan, M. Cirovic, R. Stanaszek, and S. Mueller --
The synthesis and organic houses of 3'- and 4'-thiodeoxyneamines and 4'-thiodeoxykanamycin B / Thomas W. Ku, Robert D. Sitrin, David J. Cooper, John R.E. Hoover, and Jerry A. Weisbach --
Synthesis of analogs of kanamycin B / J.P.H. Verheyden, D.B. Repke, T.C. Tompkins, and J.G. Moffatt --
The selective N-acylation of kanamycin A / M.J. Cron, J.G. Keil, J.S. Lin, M.V. Ruggeri, and D. Walker --
Carbon-13 NMR spectra of aminoglycoside antibiotics / Takayuki Naito, Soichiro Toda, Susumu Nakagawa, and Hiroshi Kawaguchi --
The constructions of adlescent parts of the fortimicin complicated / J.B. McAlpine, R.S. Egan, R.S. Stanaszek, M. Cirovic, S.L. Mueller, R.E. Carney, P. Collum, E.E. Fager, A.W. Goldstein, D.J. Grampovnik, P. Kurath, J.R. Martin, G.G. publish, J.H. Seely, and J. Tadanier --
The constructions of recent fortimicins having double bonds of their purpurosamine moieties / Kunikatsu Shirahata, Gen Shimura, Seigo Takasawa, Takao Iida, and Keiichi Takahashi --
Enzymes enhancing aminocyclitol antibiotics and their roles in resistance decision and biosynthesis / Julian Davies --
Biosynthesis and mutasynthesis of aminocyclitol antibiotics / Kenneth L. Rinehart, Jr. --
Chemical and organic amendment of antibiotics of the gentamicin workforce --
P.J.L. Daniels, D.F. Rane, S.W. McCombie, R.T. Testa, J.J. Wright, and T.L. Nagabhushan --
Synthesis and mutasynthesis of pseudosaccharides concerning aminocyclitol-glycoside antibiotics / J. Cléophax, A. Roland, C. Colas, L. Castellanos, S.D. Géro, A.M. Sepulchre, and B. Quiclet --
a number of interactions of aminoglycoside antibiotics with ribosomes / Bernard D. Davis and Phang-C. Tai.

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Extra resources for Aminocyclitol Antibiotics

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52. , Tsuchiya, T . , Umezawa, S. and Umezawa, H . , J. Antibiot. (Tokyo), (1976), 29, 978. 53. Sano, H . , Tsuchiya, T . , Umezawa, S. and Umezawa, H . , Bull. Chem. Soc. , (1977), 50, 975. 54. Yamasaki, T . , Tsuchiya, T. , J. Antibiot. (Tokyo), (1978), 31, 1233. 55. Tsuchiya, T . , Nakamura, F . , Usui, T . , Kitamura, M. , (1978), 3365. RECEIVED November 15, 1979. ch003 Department of Applied Chemistry, Faculty of Engineering, Keio University, Hiyoshi, Yokohama 223, Japan Chemical and biological modifications of aminocyclitol antibiotics have been extensively studied to elucidate a structure-antimicrobial activity relationship.

5,6-Dideoxyneamine (Y) was prepared ( F i g . 8 ) . When compound H was t r e a t e d w i t h an excess amount of methanesulfonyl c h l o r i d e i n p y r i d i n e , 5,6-di-0-mesyl d e r i v a t i v e (V) was obtained i n 64% y i e l d as c r y s t a l s . Compound V was heated w i t h z i n c powder and sodium i o d i d e i n DMF t o give a 5-ene d e r i v a t i v e (W) i n 43% y i e l d . C a t a l y t i c hydrogénation of W, followed by h y d r o l y s i s i n aqueous barium hydroxide s o l u t i o n afforded Y (6).

And Kitazawa, E . , J. Antibiot. (Tokyo), (1967), A20, 53. , Tatsuta, K. , J. Antibiot. (Tokyo), (1968), 21, 367. , Tatsuta, K. , Bull. Chem. Soc. , (1969), 42, 533. , Nishimura, Y. and Tsumura, T . , J. Antibiot. (Tokyo), (1968), 21, 424. , Nishimura, Y. and Tsumura, T . , Bull. Chem. Soc. , (1969), 42, 537. , Tatsuta, K. and Tsumura, T . , J. Antibiot. (Tokyo), (1968), 21, 162. , Tatsuta, K. and Tsumura, T . , Bull. Chem. Soc. , (1969), 42, 529. , Tsuchiya, T . , Umezawa, S. , J. Antibiot. (Tokyo), (1972), 25, 741.

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