Acute Coronary Syndromes in Clinical Practice by Deepak L. Bhatt, Anthony A Bavry

By Deepak L. Bhatt, Anthony A Bavry

Acute coronary syndromes (ACS) is an umbrella time period used to explain a chain of symptoms indicative of myocardial ischemia, comprising volatile angina, non-ST phase elevation myocardial infarction, and ST phase elevation myocardial infarction.

Managing Acute Coronary Syndromes in medical perform is a vital source for the clinician within the administration of ACS. as well as supplying a complete evaluation of the epidemiology and medical presentation of ACS, it additionally courses the reader via hazard overview, hazard stratification, prognosis, and therapy of ACS. The ebook concludes with a dialogue on rising applied sciences within the remedy of ACS. The guide structure and abundant use of illustrations make this pocketbook a great source for basic Practitioners, Emergency drugs Physicians, Nurses, Nurse Practitioners, Pharmacists, healthcare professional Trainees, clinical scholars, Nursing scholars, and Paramedics who desire to continue up to date with fresh advances within the knowing and therapy of ACS.

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The half-life of fondaparinux is approximately 17 hours, which makes once-daily dosing possible. The fifth OASIS (Organization to Assess Strategies in Acute Ischemic Syndromes) trial studied 20,078 patients with non-ST-elevation ACS [18]. Patients were randomized to either fondaparinux or enoxaparin. The primary outcome (death, myocardial infarction, or refractory ischemia) was similar between the two groups at 9 days. There was a 2% absolute decrease in major bleeding from the use of fondaparinux.

Keeley EC, Boura JA, Grines CL. Comparison of primary and facilitated percutaneous coronary interventions for ST-elevation myocardial infarction: quantitative review of randomized trials. Lancet 2006; 367:579–588. 30. FINESSE: Abciximab-only- and lytic/abciximab-facilitated PCI no better than primary PCI. com/viewarticle/562390. Last accessed January 2008. 31. ; TARGET Investigators. Do Tirofiban and ReoPro Give Similar Efficacy Trial. Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization.

22. Chew DP, Bhatt DL, Sapp S, et al. Increased mortality with oral platelet glycoprotein IIb/ IIIa antagonists: a meta-analysis of phase III multicenter randomized trials. Circulation 2001; 103:201–206. 23. Quinn MJ, Plow EF, Topol EJ. Platelet glycoprotein IIb/IIIa inhibitors: recognition of a twoedged sword? Circulation 2002; 106:379–385. 24. Bhatt DL, Topol EJ. Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes. JAMA 2000; 284:1549–1558. 25. Boersma E, Harrington RA, Moliterno DJ, et al.

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